Hello Michael, It's been a couple of years since my last organization migrated in a Hybrid scenario to Office 365. We had a Cisco Ironport device that handled email content similar to the Sophos UTM. Obsidian magic. We set up send and receive connectors to the Cisco Ironport that was in-between Office 365 and our on-Premise Exchange servers. Eventually we phased out the Ironport and had all filtering done by Office 365.

HTTPS Sophos UTM Manager IP Address 192.168.2.200 Sophos UTM (UTM01) Port 4433 Ext. IP Address 65.227.28.232 WebAdmin Port 4444 Port 4433 InternetInte Sophos UTM (UTM03) Sophos UTM (UTM04) Sophos UTM (UTM02) Sophos UTM (UTM06) Sophos UTM (UTM07) Sophos UTM (UTM05) Sophos UTM (UTM08) Customer/Of®ce 1 Customer/Of®ce 2 Port 4422 Gateway Manager. Welcome to the Sophos Community The Sophos Community is a platform for users to connect and engage on everything Sophos-related. Visit a Community group to start a discussion, ask/answer a question, subscribe to a blog, and interact with other Community members. Check out our getting started page to learn more!

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I can say that when we configured our email to go through Office 365 we HAD to change the MX records to point to their servers. Not sure you can set up your Sophos UTM as the main MX and then route through Office 365. You may get errors in Office 365 when it checks for your domain's DNS settings.

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Status page provided by StatusCast. closed Latest Status Update: 4/1/21 19:00 UTC - At approximately 18:00 EDT / 22:00 UTC on 3/26/21 a maintenance script was executed on Sophos Central that caused a number of Partner Administrator accounts to lose their role assignments and as a result Partner/Customer User accounts affected by this issue may not have visibility to data, including. Join today and get instant access.You can manage your product licenses here. Plus, you'll get a free, fully-functional home use license for Sophos UTM. Here is a great step by step help article for you or your clients for installing and logging into the Sophos SSL VPN Client. Step 1: Open your preferred web browser (Ex: Google Chrome) Step 2: At the top of your browser in the address bar, enter the public IP address of your network (Ex: https://169.254.30.211).

I would keep the MX pointed to Office 365, set up send and receive connectors back to your Sophos device as a middle-man.

The link below has some good guidance.

Sophos Utm Community Edition

Mail flow best practices for Exchange Online and Office 365 (overview)

That's my take.

Sophos Utm Community Access

Sophos Utm Review

Hope it sheds some light .